Genistein

Isoflavone CFTR potentiator

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Genistein is a soy-derived isoflavone and phytoestrogen. It is available as a dietary supplement. Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin. It exhibits antioxidant, antiangiogenic and immunosuppressive activities. It is being investigated in connection to cardiovascular disease prevention in postmenopausal women. In relation to cystic fibrosis, our AIM tool found the data that genistein can help activate CFTR chloride channels.

Genistein on PubChem
Genistein on DrugBank
Genistein on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

soybeans, fava beans, lupin, kudzu, psoralea, Flemingia vestita, Flemingia macrophylla, coffee
Structure not available

C15H10O5

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
8SA
1 5.08
Link Tested on Impact factor Notes
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. hamster cell cultures 5.08
F508del
4 3.96
Link Tested on Impact factor Notes
Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms. murine cell cultures 3.08
Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein human cell cultures 3.49 Only after 4-phenylbutyrate treatment.
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. hamster cell cultures 5.08
Consuming Genistein Improves Survival Rates in the Absence of Laxative in ΔF508-CF Female Mice mice 4.17
G551D
4 3.64
Link Tested on Impact factor Notes
Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines. human cell cultures 2.81 Less efective than CP7q.
Curcumin and genistein additively potentiate G551D-CFTR hamster cell cultures 3.19 More effective in combination with curcumin.
Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein human cell cultures 3.49
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. hamster cell cultures 5.08
S1045Y
1 3.78
Link Tested on Impact factor Notes
Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation human cell cultures 3.78

Does not treat

Mutation Number of sources Average impact factor