Curcumin

CFTR potentiator

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Curcumin is a bright yellow substance produced by Curcuma longa plants. It exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing and antimicrobial activities. While it is not approved as a medical product, it is sold as an herbal supplement, cosmetics ingredient, and food coloring and flavoring. In relation to cystic fibrosis, our AIM tool found the data that curcumin can help potentiate G551D-CFTR and W1282X-CFTR channels and restore the expression of F508del-CFTR in the plasma membrane.

Curcumin on PubChem
Curcumin on DrugBank
Curcumin on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

turmeric

C₂₁H₂₀O₆

Drug-Mutation Relation

Treats

Mutation

Number of sources

Average impact factor

F508del

4.49

Link	Tested on	Impact factor	Notes
Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines.	human cell cultures	4.49

G551D

3.19

Link	Tested on	Impact factor	Notes
Curcumin and genistein additively potentiate G551D-CFTR	hamster cell cultures	3.19	More effective in combination with genistein.

W1282X

2.81

Link	Tested on	Impact factor	Notes
Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators	human cell cultures	2.81	Better in combination with ivacaftor.

Does not treat