NB54

Aminoglycoside capable of translational readthrough

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

N/A

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

Structure image not available

N/A

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
G542X
2 4.94
Link Tested on Impact factor Notes
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. in vitro 5.21 More effective than NB30, gentamicin or paromomycin individually. Less toxic than gentamicin or paromomycin.
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54. human cell cultures 4.67 Less toxic and just as effective as gentamicin.
G542X/F508del
1 4.67
Link Tested on Impact factor Notes
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54. human cell cultures 4.67 Partial rescue.
W1282X
2 4.94
Link Tested on Impact factor Notes
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. in vitro 5.21 More effective than NB30, gentamicin or paromomycin individually. Less toxic than gentamicin or paromomycin.
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54. human cell cultures 4.67

Does not treat

Mutation Number of sources Average impact factor
F508del/F508del
1 4.67
Link Tested on Impact factor Notes
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54. human cell cultures 4.67