Ciclopirox

CFTR corrector

Phase of research

FDA-approved for Other Purpose

How it helps

Restore CFTR Function

General information

Ciclopirox is a synthetic antifungal agent. It is approved for medical use and sold under many brand names worldwide. It is used for the topical dermatologic treatment of mycoses, mainly against Tinea versicolor. Ciclopirox also shows antibacterial and anti-inflammatory properties. In relation to cystic fibrosis, our AIM tool found the data that ciclopirox can help correct F508del-CFTR by altering the cell transcriptome.

Ciclopirox on PubChem
Ciclopirox on DrugBank
Ciclopirox on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

Structure not available

C12H17NO2

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 3.71
Link Tested on Impact factor Notes
Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling. human cell cultures 3.71 More effective than corr-4a and VRT-325. Effective in a bronchial epithelial cell line but not effective in native epithelial cells.

Does not treat

Mutation Number of sources Average impact factor