Hepatocyte growth factor

Enhances functional rescue of Phe508del-CFTR

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

Hepatocyte growth factor is a substance naturally present in our cells. It regulates cell growth, cell motility, and morphogenesis by activating a signaling cascade. Hepatocyte growth factor plays a central role in angiogenesis, tumorogenesis and tissue regeneration. It is being studied as a potential treatment for coronary artery disease and for damage to the heart following myocardial infarction. In relation to cystic fibrosis, our AIM tool found the data that hepatocyte growth factor can help enhance the chemical correction of F508del-CFTR.

Hepatocyte growth factor on Wikipedia

Synonyms

HGF

Marketed as

N/A

Dietary sources

N/A

Structure image not available

N/A

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 4.01
Link Tested on Impact factor Notes
Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR human cell cultures 4.01 Only in combination with lumacaftor and ivacaftor. Better than just the combination of lumacaftor with ivacaftor.

Does not treat

Mutation Number of sources Average impact factor