9-aminoacridine

Small molecule CFTR corrector

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

9-aminoacridine is an experimental substance used in studies and not yet available as a human pharmaceutical. It is a small-molecule drug with antiseptic and mutagenic properties. In relation to cystic fibrosis, our AIM tool found the data that 9-aminoacridine induces the expression of many genes, which leads to the correction of the F508del defect.

9-aminoacridine on PubChem
9-aminoacridine on DrugBank
9-aminoacridine on Wikipedia

Synonyms

Aminacrine

Marketed as

N/A

Dietary sources

N/A

Structure not available

C13H10N2

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 3.54
Link Tested on Impact factor Notes
RESCUE OF THE MUTANT CFTR CHLORIDE CHANNEL BY PHARMACOLOGICAL CORRECTORS AND LOW TEMPERATURE ANALYZED BY GENE EXPRESSION PROFILING human cell cultures 3.54 More effective than corr-4a and VRT-325. Effective in a bronchial epithelial cell line but not effective in native epithelial cells.

Does not treat

Mutation Number of sources Average impact factor