Epigallocatechin gallate

Flavonoid improving CFTR function

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Epigallocatechin gallate is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is used in many dietary supplements and studied as a potential cancer chemopreventive agent. In relation to cystic fibrosis, our AIM tool found the data that epigallocatechin gallate can help improve CFTR function in patients with F508del-CFTR mutation.

Epigallocatechin gallate on PubChem
Epigallocatechin gallate on DrugBank
Epigallocatechin gallate on Wikipedia

Synonyms

EGCG

Marketed as

N/A

Dietary sources

green tea, white tea, black tea, apple skin, plums, onions, hazelnuts, pecans, carob powder

C₂₂H₁₈O₁₁

Drug-Mutation Relation

Treats

Mutation

Number of sources

Average impact factor

F508del

11.75

Link	Tested on	Impact factor	Notes
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation	mice	11.75	Only effective following cysteamine treatment.

Does not treat

Mutation	Number of sources	Average impact factor