1-EBIO

CFTR potentiator

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

1-EBIO is an experimental substance used in studies and not yet available as a human pharmaceutical. Based on its characteristics as a calcium channel agonist, it has the potential to combat cardiac failure and endocrinological disorders.  In relation to cystic fibrosis, our AIM tool found the data that 1-EBIO can help potentiate mutant CFTR channels that have a residual function.

1-EBIO on PubChem

Synonyms

1-ethyl-2-benzimidazolone

Marketed as

N/A

Dietary sources

N/A

Structure not available

C9H10N2O

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
R334W/X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/3849+10kbC->T
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/3272-26A->G
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/Y161C
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
dele2,3/X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/G576A
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/4005+572A->G
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
1898+3A->G/1898+3A->G
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/T338I
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
R334W/3199del6
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/I1234V
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F1052V/M1137R
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/R334W
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
N1303K/R334W
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/V232D
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09

Does not treat

Mutation Number of sources Average impact factor
A561E/A561E
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/120del23
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/1525-1 G->A
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/182delT
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/A561E
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/F508del
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/G542X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/G85E
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/N1303K
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/Q39X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/Q552X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/W57X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
F508del/Y1092X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
G85E/G85E
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
Q552X/R1162X
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
R1158X/2183AA->G
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
R1158X/R560T
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09
R764X/1717-1 G->A
1 4.09
Link Tested on Impact factor Notes
The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients human cell cultures 4.09