Imperatorin 

Chinese medicinal herbs coumarin compound, F508del-CFTR activator

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Imperatorin is a furocoumarin and phytochemical substance present in some plants. It is a major constituent of many herbal medicines, mainly Chinese medicinal herbs, and possesses anti-osteoporosis activity. In relation to cystic fibrosis, our AIM tool found the data that imperatorin can help rescue F508del-CFTR.

Imperatorin on PubChem
Imperatorin on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

Urena lobata, Angelica archangelica, Angelica dahurica, Glehnia littoralis, Saposhnikovia divaricata, Cnidium monnieri, Incarvillea younghusbandii, Zanthoxylum americanum
Structure not available

C16H14O4

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 2.20
Link Tested on Impact factor Notes
Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating. rat cell cultures 2.20

Does not treat

Mutation Number of sources Average impact factor