Sildenafil 

CFTR activator

Phase of research

FDA-/EMA-approved for Other Purpose

How it helps

Restore CFTR Function

General information

N/A

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

Structure not available

C22H30N6O4S

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
2 7.85
Link Tested on Impact factor Notes
Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. mice 9.79
Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice mice 5.90 Less effective than vardenafil or tadalafil.

Does not treat

Mutation Number of sources Average impact factor