NB54

Aminoglycoside capable of translational readthrough

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

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Synonyms

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Marketed as

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Dietary sources

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Structure image not available

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Drug-Mutation Relation

results for R352Q / G542X
See all data on NB54

Treats

Mutation Link Tested on Impact factor Notes
G542X Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. in vitro 5.21 More effective than NB30, gentamicin or paromomycin individually. Less toxic than gentamicin or paromomycin.
G542X Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54. human cell cultures 4.67 Less toxic and just as effective as gentamicin.

Does not treat

Mutation Link Tested on Impact factor Notes