NB30

Aminoglycoside capable of translational readthrough

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

N/A

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

Structure image not available

N/A

Drug-Mutation Relation

Treats

Mutation

Number of sources

Average impact factor

G542X

1

5.21

Link	Tested on	Impact factor	Notes
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.	in vitro	5.21	Less effective than NB54, gentamicin or paromomycin individually. Less toxic than gentamicin or paromomycin.

W1282X

2

4.94

Link	Tested on	Impact factor	Notes
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54.	human cell cultures	4.67
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.	in vitro	5.21	Less effective than NB54, gentamicin or paromomycin individually. Less toxic than gentamicin or paromomycin.

Does not treat

Mutation	Number of sources	Average impact factor