IGF-1

Enhances protein expression of CFTR

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

IGF-1 is a substance naturally present in our cells. It is a hormone produced mainly by the liver, with a similar structure to insulin. It plays an important role in childhood growth. To treat growth failure, a synthetic analog of IGF-1, named mecasermin, is used.  In relation to cystic fibrosis, our AIM tool found the data that IGF-1 can help treat F508del-CFTR by enhancing the protein expression of CFTR.

IGF-1 on Wikipedia

Synonyms

Insulin-Like Growth Factor 1

Marketed as

N/A

Dietary sources

N/A

Structure image not available

N/A

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 3.53
Link Tested on Impact factor Notes
Insulin-Like Growth Factor 1 (IGF-1) Enhances the Protein Expression of CFTR human cell cultures 3.53 Effective only in combination with CFTR correctors.

Does not treat

Mutation Number of sources Average impact factor