Ibuprofen

Non-steroidal anti-inflammatory drug and CFTR corrector

Phase of research

FDA-/EMA-approved for Other Purpose

How it helps

Anti-Inflammatory

General information

Ibuprofen is a nonsteroidal anti-inflammatory medical drug (NSAID). It is used to treat pain, fever, and inflammation. It has been used as a medical product since the early 1970s marketed under multiple brand names. Ibuprofen is mostly used to treat fever, painful menstruation, osteoarthritis, dental pain, headaches and pain from kidney stones.  In relation to cystic fibrosis, our AIM tool found the data that Ibuprofen can help preserve lung function thanks to its anti-inflammatory properties and can also help rescue F508del-CFTR.

Ibuprofen on PubChem
Ibuprofen on DrugBank
Ibuprofen on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

Structure not available

C13H18O2

Drug-Mutation Relation

results for 1677delTA / G542X
See all data on Ibuprofen

Treats

Mutation Link Tested on Impact factor Notes
General effect Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells human cell cultures 4.28
General effect Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis. humans 4.03
General effect Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis. humans 9.07
General effect Effect of high-dose ibuprofen in patients with cystic fibrosis. humans N/A

Does not treat

Mutation Link Tested on Impact factor Notes