Ibuprofen

Non-steroidal anti-inflammatory drug and CFTR corrector

Phase of research

FDA-/EMA-approved for Other Purpose

How it helps

Anti-Inflammatory

General information

Ibuprofen is a nonsteroidal anti-inflammatory medical drug (NSAID). It is used to treat pain, fever, and inflammation. It has been used as a medical product since the early 1970s marketed under multiple brand names. Ibuprofen is mostly used to treat fever, painful menstruation, osteoarthritis, dental pain, headaches and pain from kidney stones. In relation to cystic fibrosis, our AIM tool found the data that Ibuprofen can help preserve lung function thanks to its anti-inflammatory properties and can also help rescue F508del-CFTR.

Ibuprofen on PubChem
Ibuprofen on DrugBank
Ibuprofen on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

C₁₃H₁₈O₂

Drug-Mutation Relation

Treats

Mutation

Number of sources

Average impact factor

F508del/F508del

3.85

Link	Tested on	Impact factor	Notes
Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking	mice	3.85

General effect

5.79

Link	Tested on	Impact factor
Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells	human cell cultures	4.28
Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis.	humans	4.03
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.	humans	9.07
Effect of high-dose ibuprofen in patients with cystic fibrosis.	humans	N/A

Does not treat

Mutation	Number of sources	Average impact factor