Genistein

Isoflavone CFTR potentiator

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Genistein is a soy-derived isoflavone and phytoestrogen. It is available as a dietary supplement. Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin. It exhibits antioxidant, antiangiogenic and immunosuppressive activities. It is being investigated in connection to cardiovascular disease prevention in postmenopausal women. In relation to cystic fibrosis, our AIM tool found the data that genistein can help activate CFTR chloride channels.

Genistein on PubChem
Genistein on DrugBank
Genistein on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

soybeans, fava beans, lupin, kudzu, psoralea, Flemingia vestita, Flemingia macrophylla, coffee

C₁₅H₁₀O₅

Drug-Mutation Relation

results for D1152H / F508del

See all data on Genistein

Treats

Mutation	Link	Tested on	Impact factor	Notes
F508del	Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms.	murine cell cultures	3.08
F508del	Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein	human cell cultures	3.49	Only after 4-phenylbutyrate treatment.
F508del	Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.	hamster cell cultures	5.08
F508del	Consuming Genistein Improves Survival Rates in the Absence of Laxative in ΔF508-CF Female Mice	mice	4.17

Does not treat

Mutation	Link	Tested on	Impact factor	Notes