ETX001

TMEM16A potentiator

Phase of research

Pre-clinical

How it helps

Mucociliary Clearance

General information

ETX001 is an experimental substance used in studies and not yet available as a human pharmaceutical. It potentiates TMEM16, a CFTR chloride channel in epithelial cells. In relation to cystic fibrosis, our AIM tool found the data that ETX001 can help enhance mucus clearance independent of CFTR function.

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

Structure image not available

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
General effect
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. sheep 16.49
F508del/621+1G->T
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. human cell cultures 16.49
F508del/F508del
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. human cell cultures 16.49
F508del/G542X
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. human cell cultures 16.49
F508del/G85E
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. human cell cultures 16.49
F508del/R553X
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. human cell cultures 16.49
F508del/R709X
1 16.49
Link Tested on Impact factor Notes
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. human cell cultures 16.49

Does not treat

Mutation Number of sources Average impact factor