Equol

Flavonoid activator of CFTR

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Equol is an isoflavandiol estrogen metabolized from a type of isoflavone in soybeans and other plant sources by bacterial flora in the intestines. It is being developed as a treatment of menopausal symptoms and studies also in terms of breast cancer treatment. In relation to cystic fibrosis, our AIM tool found the data that equol can help activate F508del-CFTR. 

Equol on PubChem
Equol on DrugBank

Synonyms

4',7-isoflavandiol

Marketed as

N/A

Dietary sources

soybeans
Structure not available

C15H14O3

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 4.43
Link Tested on Impact factor Notes
Activation of the Cystic Fibrosis Transmembrane Conductance Regulator by the Flavonoid Quercetin human cell cultures 4.43 Less safe than quercetin.

Does not treat

Mutation Number of sources Average impact factor