Epigallocatechin gallate

Flavonoid improving CFTR function

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Epigallocatechin gallate is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is used in many dietary supplements and studied as a potential cancer chemopreventive agent.  In relation to cystic fibrosis, our AIM tool found the data that epigallocatechin gallate can help improve CFTR function in patients with F508del-CFTR mutation.

Epigallocatechin gallate on PubChem
Epigallocatechin gallate on DrugBank
Epigallocatechin gallate on Wikipedia

Synonyms

EGCG

Marketed as

N/A

Dietary sources

green tea, white tea, black tea, apple skin, plums, onions, hazelnuts, pecans, carob powder
Structure not available

C22H18O11

Drug-Mutation Relation

results for D1152H / F508del
See all data on Epigallocatechin gallate

Treats

Mutation Link Tested on Impact factor Notes
F508del Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation mice 11.75 Only effective following cysteamine treatment.

Does not treat

Mutation Link Tested on Impact factor Notes