Curcumin
CFTR potentiator
General information
Curcumin is a bright yellow substance produced by Curcuma longa plants. It exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing and antimicrobial activities. While it is not approved as a medical product, it is sold as an herbal supplement, cosmetics ingredient, and food coloring and flavoring. In relation to cystic fibrosis, our AIM tool found the data that curcumin can help potentiate G551D-CFTR and W1282X-CFTR channels and restore the expression of F508del-CFTR in the plasma membrane.
Curcumin on PubChem
Curcumin on DrugBank
Curcumin on Wikipedia
Synonyms
N/A
Marketed as
N/A
Dietary sources
turmeric
C21H20O6
Drug-Mutation Relation
results for W1282X / R792X
See all data on CurcuminTreats
| Mutation | Link | Tested on | Impact factor | Notes |
|---|---|---|---|---|
| W1282X | Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators | human cell cultures | 2.81 | Better in combination with ivacaftor. |
Does not treat
| Mutation | Link | Tested on | Impact factor | Notes |
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