Curcumin

CFTR potentiator

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function


General information

Curcumin is a bright yellow substance produced by Curcuma longa plants. It exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing and antimicrobial activities. While it is not approved as a medical product, it is sold as an herbal supplement, cosmetics ingredient, and food coloring and flavoring. In relation to cystic fibrosis, our AIM tool found the data that curcumin can help potentiate G551D-CFTR and W1282X-CFTR channels and restore the expression of F508del-CFTR in the plasma membrane. 

Curcumin on PubChem
Curcumin on DrugBank
Curcumin on Wikipedia


Synonyms

N/A


Marketed as

N/A


Dietary sources

turmeric
Structure not available

C21H20O6


Drug-Mutation Relation

results for W1282X / R792X
See all data on Curcumin

Treats

Mutation Link Tested on Impact factor Notes
W1282X Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators human cell cultures 2.81 Better in combination with ivacaftor.

Does not treat

Mutation Link Tested on Impact factor Notes