Cholera toxin

Rescues endogenous misfolded proteins

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

Cholera toxin is a protein complex secreted by the bacterium Vibrio cholerae. It is responsible for the massive, watery characteristics of cholera infection. It has multiple subunits and the B subunit appears to be relatively non-toxic, which enables its applications in cell and molecular biology. In relation to cystic fibrosis, our AIM tool found the data that cholera toxin can help rescue F508del-CFTR from degradation.

Cholera toxin on Wikipedia

Synonyms

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Marketed as

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Dietary sources

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Structure image not available

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Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 2.81
Link Tested on Impact factor Notes
Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases human cell cultures 2.81

Does not treat

Mutation Number of sources Average impact factor