Capsaicin

CFTR potentiator

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Capsaicin is an active component of chili peppers. It is used as an analgesic in topical ointments and dermal patches to relieve pain and to reduce the symptoms of peripheral neuropathy. It is FDA-approved and sold under the name Qutenza® since 2009. In relation to cystic fibrosis, our AIM tool found the data that capsaicin can potentiate cAMP-stimulated G551D-CFTR, F508del-CFTR, and 8SA-CFTR channels. 

Capsaicin on PubChem
Capsaicin on DrugBank
Capsaicin on Wikipedia

Synonyms

N/A

Marketed as

Dietary sources

chilli peppers
Structure not available

C18H27NO3

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
8SA
1 5.08
Link Tested on Impact factor Notes
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. hamster cell cultures 5.08
F508del
1 5.08
Link Tested on Impact factor Notes
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. hamster cell cultures 5.08
G551D
1 5.08
Link Tested on Impact factor Notes
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. hamster cell cultures 5.08

Does not treat

Mutation Number of sources Average impact factor