Apigenin

Flavonoid activator of CFTR

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Apigenin is a natural substance present in many plants, including parsley, celery, and chamomile. It exhibits antiproliferative, anti-inflammatory and antimetastatic activities, but its mechanism is unknown. It has significant promise as a skin cancer chemopreventive agent. In relation to cystic fibrosis, our AIM tool found the data that apigenin can activate G551D-CFTR and also F508del-CFTR present at the cell surface.

Apigenin on PubChem
Apigenin on DrugBank
Apigenin on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

parsley, celery, celeriac, chamomile
Structure not available

C15H10O5

Drug-Mutation Relation

results for D1152H / F508del
See all data on Apigenin

Treats

Mutation Link Tested on Impact factor Notes
F508del Activation of the Cystic Fibrosis Transmembrane Conductance Regulator by the Flavonoid Quercetin human cell cultures 4.43 Less safe than quercetin.

Does not treat

Mutation Link Tested on Impact factor Notes