Apigenin

Flavonoid activator of CFTR

Phase of research

Accessible Dietary Supplement

How it helps

Restore CFTR Function

General information

Apigenin is a natural substance present in many plants, including parsley, celery, and chamomile. It exhibits antiproliferative, anti-inflammatory and antimetastatic activities, but its mechanism is unknown. It has significant promise as a skin cancer chemopreventive agent. In relation to cystic fibrosis, our AIM tool found the data that apigenin can activate G551D-CFTR and also F508del-CFTR present at the cell surface.

Apigenin on PubChem
Apigenin on DrugBank
Apigenin on Wikipedia

Synonyms

N/A

Marketed as

N/A

Dietary sources

parsley, celery, celeriac, chamomile
Structure not available

C15H10O5

Drug-Mutation Relation

Treats

Mutation Number of sources Average impact factor
F508del
1 4.43
Link Tested on Impact factor Notes
Activation of the Cystic Fibrosis Transmembrane Conductance Regulator by the Flavonoid Quercetin human cell cultures 4.43 Less safe than quercetin.
G551D
1 2.19
Link Tested on Impact factor Notes
Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. rat cell cultures 2.19

Does not treat

Mutation Number of sources Average impact factor