GLPG2451

Small molecule CFTR potentiator

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

GLPG2451 is an experimental substance used in studies and not yet available as a human pharmaceutical. In relation to cystic fibrosis, our AIM tool found the data that GLPG2451 can help potentiate G178R-, G551D-, S549N- and R117H-CFTR channels and also corrector-rescued F508del-CFTR.

GLPG2451 on PubChem

Synonyms

N/A

Marketed as

N/A

Dietary sources

N/A

C₁₆H₁₆F₃N₃O₅S

Drug-Mutation Relation

results for D1152H / F508del

See all data on GLPG2451

Treats

Mutation	Link	Tested on	Impact factor	Notes
F508del	Identification and Characterization of Novel CFTR Potentiators	human cell cultures	3.85	In combination with F508del correction. Better than ivacaftor.

Does not treat

Mutation	Link	Tested on	Impact factor	Notes