G418

Aminoglycoside antibiotic capable of translational readthrough

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

G418 is an aminoglycoside antibiotic produced by Micromonospora rhodorangea. It is routinely used in laboratory research as a selective agent to select genetically engineered cells. In relation to cystic fibrosis, our AIM tool found the data that G418 can suppress nonsense CFTR mutations, namely G542X, R553X and W1282X, by suppressing their premature stop signal. This leads to the expression of full-length CFTR protein at the cell membrane.

G418 on PubChem
G418 on DrugBank
G418 on Wikipedia

 

Synonyms

geneticin

Marketed as

N/A

Dietary sources

N/A

Structure not available

C20H40N4O10

Drug-Mutation Relation

results for R352Q / G542X
See all data on G418

Treats

Mutation Link Tested on Impact factor Notes
G542X A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies mice 2.78
G542X Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. human cell cultures 28.14

Does not treat

Mutation Link Tested on Impact factor Notes