Endothelin 1

CFTR corrector

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

Endothelin 1 is a protein naturally present in our cells. It is produced by vascular endothelial cells and a potent vasoconstrictor. In relation to cystic fibrosis, our AIM tool found the data that endothelin 1 can help correct the F508del-CFTR function.

Endothelin 1 on PubChem
Endothelin 1 on DrugBank
Endothelin 1 on Wikipedia

Synonyms

ET-1

Marketed as

N/A

Dietary sources

N/A

Structure image not available

C₁₀₉H₁₅₉N₂₅O₃₂S₅

Drug-Mutation Relation

results for D1152H / F508del

See all data on Endothelin 1

Treats

Mutation	Link	Tested on	Impact factor	Notes
F508del	High-content Functional Screen to Identify Proteins that Correct F508del-CFTR Function*S⃞	human cell cultures	7.52

Does not treat

Mutation	Link	Tested on	Impact factor	Notes