ALLN

Proteasome inhibitor preventing premature CFTR breakdown

Phase of research

Pre-clinical

How it helps

Restore CFTR Function

General information

ALLN is a substance used in experimental studies and not yet available as a human pharmaceutical. It inhibits natural cysteine proteases and the proteasome. In relation to cystic fibrosis, our AIM tool found the data that ALLN improves rescue of F508del CFTR function by preventing its degradation.

ALLN

Synonyms

Proteasome Inhibitor V

Marketed as

N/A

Dietary sources

N/A

Structure image not available

N/A

Drug-Mutation Relation

results for D1152H / F508del

See all data on ALLN

Treats

Mutation	Link	Tested on	Impact factor	Notes
F508del	Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors	murine cell cultures	3.73

Does not treat

Mutation	Link	Tested on	Impact factor	Notes